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CyFlow™ CD71 APC-Cy7

CyFlow™ CD71 APC-Cy7
Alternative Name: T9 , TFR, TRFR
Antibody: Yes
Antigen: CD71
Clonality: monoclonal
Clone: MEM-75
Emission Maximum: 780 nm
Excitation Maximum: 650 nm, 750 nm
Field of Interest: Endocytosis, Immunophenotyping
Format/Fluorochrome: APC-Cy7
Isotype: IgG1
Laser: Red
Regulatory Status: ASR
Source Species: Mouse
Target Species: Human
Product number: BD471787

Analytical and performance characteristics are not established

$515.00 USD*

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Description
HLDA Workshop HLDA IV—WS Code A 45 HLDA V—WS Code T T-165 Concentration Unit µg/mL... more
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CyFlow™ CD71 APC-Cy7

HLDA WorkshopHLDA IV—WS Code A 45 HLDA V—WS Code T T-165
Concentration Unitµg/mL
Concentration50
Volume1.0 mL
ImmunogenNALM-6 human pre-B cell line
Antigen DistributionCD71 (T9, TFR, TRFR) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. Upon binding of holotransferrin (complex of transferrin and iron ions), CD71 is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with CD71 and recycles to the cell surface, where it is released upon exposure to normal pH. CD71 is also involved in uptake of non-transferrin bound iron.
UsageThe reagent may have application in various test methodologies, including Flow Cytometry. Vial has sufficient volume for 100 tests, if used at 10 μL·/·test. User has responsibility for determining reagent quantity per test for any ASR reagent.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Knapp W, Dorken B, Gilks W, Rieber EP, Schmidt RE, Stein H, von dem Borne AEGK (Eds): Leucocyte Typing IV. Oxford·University·Press,·Oxford. 1989; 1‑1820. <·NLM·ID:·8914679·> | Takeichi M: Cadherin cell adhesion receptors as a morphogenetic regulator. Science. 1991·Mar·22; 251(5000):1451‑5. <·PMID:·2006419·> | Doussis IA, Gatter KC, Mason DY: CD68 reactivity of non‑macrophage derived tumours in cytological specimens. J·Clin·Pathol. 1993·Apr; 46(4):334‑6. <·PMID:·7684403·> | Grabbe S, Varga G, Beissert S, Steinert M, Pendl G, Seeliger S, Bloch W, Peters T, Schwarz T, Sunderkötter C, Scharffetter-Kochanek K: Beta2 integrins are required for skin homing of primed T cells but not for priming naive T cells. J·Clin·Invest. 2002·Jan; 109(2):183‑92. <·PMID:·11805130·> | Rouas-Freiss N, Moreau P, Ferrone S, Carosella ED: HLA‑G proteins in cancer: do they provide tumor cells with an escape mechanism?. Cancer·Res. 2005·Nov·15; 65(22):10139‑44. <·PMID:·16287995·> | Graham RM, Chua AC, Herbison CE, Olynyk JK, Trinder D: Liver iron transport. World·J·Gastroenterol. 2007·Sep·21; 13(35):4725‑36. <·PMID:·17729394·> | Beck Z, Balogh A, Kis A, Izsépi E, Cervenak L, László G, Bíró A, Liliom K, Mocsár G, Vámosi G, Füst G, Matko J: New cholesterol‑specific antibodies remodel HIV‑1 target cells' surface and inhibit their in vitro virus production. J·Lipid·Res. 2010·Feb; 51(2):286‑96. <·PMID:·19654424·>

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