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CyFlow™ Beta3-tubulin Purified

CyFlow™ Beta3-tubulin Purified
Antibody: Yes
Antigen: β3-tubulin
Application: Flow cytometry, Immunocytochemistry, Immunohistochmistry (paraffin-embedded sections), Western blot
Clonality: monoclonal
Clone: TU-20
Field of Interest: Cytoskeleton, Neurobiology
Format/Fluorochrome: Purified
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Broad Spectrum
Product number: BT516409

For Research Use Only

$120.00 USD*

Price excludes any applicable taxes plus shipping costs

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ Beta3-tubulin Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenPeptide (C) 441-448 coupled to maleimide-activated keyhole limpet hemocyanin via cysteine added to the N-terminus of the neuron-specific peptide
Background Informationβ3-tubulin isoform is present dominantly in cells of neuronal origin and it is one of the earliest markers of neuronal differentiation. It is regarded as a specific probe for the cells of neuronal origin as well as for the tumors originating from these cells. The β3-tubulin is most abundant in cells of neuronal origin, but was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Draberova E, Lukas Z, Ivanyi D, Viklicky V, Draber P: Expression of class III beta‑tubulin in normal and neoplastic human tissues.. Histochem Cell Biol. 1998 Mar; 109(3):231‑9. < PMID: 9541471 > | Peknicova J, Kubatova A, Sulimenko V, Draberova E, Viklicky V, Hozak P, Draber P: Differential subcellular distribution of tubulin epitopes in boar spermatozoa:recognition of class III beta‑tubulin epitope in sperm tail. Biol Reprod. 2001 Sep; 65(3):672‑9. < PMID: 11514327 > | Kukharskyy V, Sulimenko V, Macůrek L, Sulimenko T, Dráberová E, Dráber P: Complexes of gamma‑tubulin with nonreceptor protein tyrosine kinases Src and Fynin differentiating P19 embryonal carcinoma cells. Exp Cell Res. 2004 Aug 1; 298(1):218‑28. < PMID: 15242776 > | Jirasek T, Pisarikova E, Viklicky V, Mandys V: Expression of class III beta‑tubulin in malignant epithelial tumours: an immunohistochemical study using TU‑20 and TuJ‑1 antibodies. Folia Histochem Cytobiol. 2007; 45(1):41‑5. < PMID: 17378245 > | Katsetos CD, Dráberová E, Smejkalová B, Reddy G, Bertrand L, de Chadarévian J-P, Legido A, Nissanov J, Baas PW, Dráber P: Class III beta‑tubulin and gamma‑tubulin are co‑expressed and form complexes in human glioblastoma cells.. Neurochem Res. 2007; 32:1387‑1398. < PMID: 20162618 > | Jirásek T, Cipro S, Musilová A, Kubecová M, Mandys V: Expression of class III beta‑tubulin in colorectal carcinomas: an immunohistochemical study using TU‑20&TuJ‑1 antibody. Indian J Med Res. 2009 Jan; 129(1):89‑94. < PMID: 19287064 > | Theodorou E, Dalembert G, Heffelfinger C, White E, Weissman S, Corcoran L, Snyder M: A high throughput embryonic stem cell screen identifies Oct‑2 as a bifunctional regulator of neuronal differentiation. Genes Dev. 2009 Mar 1; 23(5):575‑88. < PMID: 19270158 > | Dráberová E, Sulimenko V, Vinopal S, Sulimenko T, Sládková V, D'Agostino L, Sobol M, Hozák P, Křen L, Katsetos CD, Dráber P: Differential expression of human γ‐tubulin isotypes during neuronal development and oxidative stress points to a γ‐tubulin‐2 prosurvival function. FASEBJ. 2017 May; 31(5):1828‐1846. < PMID: 28119396 >

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