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CyFlow™ SHIP-1 Purified

CyFlow™ SHIP-1 Purified
Antibody: Yes
Antigen: SHIP-1
Application: Flow cytometry, Western blot
Clonality: monoclonal
Clone: SHIP-02
Field of Interest: Phosphorylation
Format/Fluorochrome: Purified
Isotype: IgG2a
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: AB475048

For Research Use Only

$120.00 USD*

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ SHIP-1 Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenPeptide coresponding to a sequence within N-terminal domain of Human SHIP-1
Background InformationSHIP-1 (SH2 domain containing inositol phosphatase-1) is a 5´inositol phosphatase that regulates cell responses in lymphocytes and myeloid cells by hydrolyzing the second messenger PI (3,4,5) trisphosphate. SHIP-1 is recruited upon engagement of both inhibitory and activatory receptors, such as FcγRIIB, FcγRIII, FcεRI or cytokine and growth factor receptors, and supresses PI3K-dependent signaling, down-regulates cell migration and invasion of transformed cells and phagocytosis. SHIP-1 also serves as a scaffold for the recruitment of other proteins to the plasma membrane.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Ai J, Maturu A, Johnson W, Wang Y, Marsh CB, Tridandapani S: The inositol phosphatase SHIP‑2 down‑regulates FcgammaR‑mediated phagocytosis in murine macrophages independently of SHIP‑1. Blood. 2006 Jan 15; 107(2):813‑20. < PMID: 16179375 > | Xing W, Hamaguchi M: Effects of SHIP‑1 on MMP2 secretion and invasion of SR3Y1 cells. J Genet Genomics. 2007 Apr; 34(4):285‑93. < PMID: 17498626 > | Tarasenko T, Kole HK, Chi AW, Mentink-Kane MM, Wynn TA, Bolland S: T cell‑specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses. Proc Natl Acad Sci USA. 2007 Jul 3; 104(27):11382‑7. < PMID: 17585010 > | Harris SJ, Parry RV, Westwick J, Ward SG: Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3‑kinase signaling in T lymphocytes. J Biol Chem. 2008 Feb 1; 283(5):2465‑9. < PMID: 18073217 >

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