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CyFlow™ NK1.1 Purified

CyFlow™ NK1.1 Purified
Alternative Name: CD161bc
Antibody: Yes
Antigen: NK1.1
Application: Flow cytometry, Functional assays, Immunohistochemistry (frozen sections), Immunoprecipitation
Clonality: monoclonal
Clone: PK136
Field of Interest: Immunophenotyping, MHC
Format/Fluorochrome: Purified
Isotype: IgG2a
Regulatory Status: RUO
Source Species: Mouse
Target Species: Mouse
Product number: BV488567

For Research Use Only

$120.00 USD*

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ NK1.1 Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenNK1-positive murine splenic and bone marrow cells
Background InformationNK1.1 (CD161bc and also known as NKRP1, Ly55c, or Ly59) is a cell surface antigen expressed on NK cells and NK-T cells of certain mouse strains, which is being used for identification or antibody-mediated depletion of these cells in the respective strains. This antigen participates in NK cell activation, including production of interferon gamma, and release of cytotoxic granules.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Wang M, Ellison CA, Gartner JG, HayGlass KT: Natural killer cell depletion fails to influence initial CD4 T cell commitment in vivo in exogenous antigen‑stimulated cytokine and antibody responses. J Immunol. 1998 Feb 1; 160(3):1098‑105. < PMID: 9570522 > | Carroll JL, Nielsen LL, Pruett SB, Mathis JM: The role of natural killer cells in adenovirus‑mediated p53 gene therapy. Mol Cancer Ther. 2001 Nov; 1(1):49‑60. < PMID: 12467238 > | Símová J, Bubeník J, Bieblová J, Jandlová T: The role of NK1.1+ cells in the protection against MHC class I+ HPV16‑associated tumours. Folia Biol (Praha). 2004; 50(6):200‑2. < PMID: 15709715 > | Kulesza J, Hoser G, Wasilewska D, Kawiak J: NK cell depletion and recovery in SCID mice treated with anti‑NK1.1 antibody. Folia Histochem Cytobiol. 2006; 44(2):93‑6. < PMID: 16805133 > | Takahashi S, Kawamura T, Kanda Y, Taniguchi T, Nishizawa T, Iiai T, Hatakeyama K, Abo T: Activation of CD1d‑independent NK1.1+ T cells in the large intestine by Lactobacilli. Immunol Lett. 2006 Jan 15; 102(1):74‑8. < PMID: 16107279 > | Carlyle JR, Mesci A, Ljutic B, Belanger S, Tai LH, Rousselle E, Troke AD, Proteau MF, Makrigiannis AP: Molecular and genetic basis for strain‑dependent NK1.1 alloreactivity of mouse NK cells. J Immunol. 2006 Jun 15; 176(12):7511‑24. < PMID: 16751398 > | Fang M, Lanier LL, Sigal LJ: A role for NKG2D in NK cell‑mediated resistance to poxvirus disease. PLoS Pathog. 2008 Feb 8; 4(2):e30. < PMID: 18266471 > | Laffont S, Seillet C, Ortaldo J, Coudert JD, Guéry JC: Natural killer cells recruited into lymph nodes inhibit alloreactive T‑cell activation through perforin‑mediated killing of donor allogeneic dendritic cells. Blood. 2008 Aug 1; 112(3):661‑71. < PMID: 18505782 > | GeurtsvanKessel CH, Bergen IM, Muskens F, Boon L, Hoogsteden HC, Osterhaus AD, Rimmelzwaan GF, Lambrecht BN: Both conventional and interferon killer dendritic cells have antigen‑presenting capacity during influenza virus infection. PLoS One. 2009 Sep 28; 4(9):e7187. < PMID: 19784375 > | Joncker NT, Shifrin N, Delebecque F, Raulet DH: Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment. J Exp Med. 2010 Sep 27; 207(10):2065‑72. < PMID: 20819928 >

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