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CyFlow™ CD326 Purified

CyFlow™ CD326 Purified
Alternative Name: EGP, EGP-40, EpCAM, hEGP-2, M4S1, MIC18, MK1, TACSTD1 , TROP1
Antibody: Yes
Antigen: CD326
Application: Flow cytometry, Immunocytochemistry, Immunohistochmistry (paraffin-embedded sections), Immunoprecipitation, Western blot
Clonality: monoclonal
Clone: 323/A3
Field of Interest: Immunophenotyping
Format/Fluorochrome: Purified
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: CD624434

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ CD326 Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenHuman breast cancer MCF-7 cells
Background InformationCD326 (EpCAM, ESA, EGP40, EGP-2, KSA1/4, CO17-1A, GA733-2, MOC31, Ber-EP4) is a 40 kDa transmembrane glycoprotein serving as adhesion molecule in the basolateral membranes in a variety of epithelial cells. CD326 mediates calcium-independent homotypic cell-cell adhesions. CD326 over-expression has been detected in many epithelial tumors and is often associated with bad prognosis. It has been used for diagnostics of (pre-) malignancies at early stages.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Edwards DP, Grzyb KT, Dressler LG, Mansel RE, Zava DT, Sledge GW Jr, McGuire WL: Monoclonal antibody identification and characterization of a Mr 43,000 membrane glycoprotein associated with human breast cancer. Cancer Res. 1986 Mar; 46(3):1306‑17. < PMID: 3510721 > | Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO: Ep‑CAM: a human epithelial antigen is a homophilic cell‑cell adhesion molecule. J Cell Biol. 1994 Apr; 125(2):437‑46. < PMID: 8163559 > | Litvinov SV, Bakker HA, Gourevitch MM, Velders MP, Warnaar SO: Evidence for a role of the epithelial glycoprotein 40 (Ep‑CAM) in epithelial cell‑cell adhesion. Cell Adhes Commun. 1994 Oct; 2(5):417‑28. < PMID: 7842256 > | Balzar M, Bakker HA, Briaire-de-Bruijn IH, Fleuren GJ, Warnaar SO, Litvinov SV: Cytoplasmic tail regulates the intercellular adhesion function of the epithelial cell adhesion molecule. Mol Cell Biol. 1998 Aug; 18(8):4833‑43. < PMID: 9671492 > | Balzar M, Briaire-de Bruijn IH, Rees-Bakker HA, Prins FA, Helfrich W, de Leij L, Riethmüller G, Alberti S, Warnaar SO, Fleuren GJ, Litvinov SV: Epidermal growth factor‑like repeats mediate lateral and reciprocal interactions of Ep‑CAM molecules in homophilic adhesions. Mol Cell Biol. 2001 Apr; 21(7):2570‑80. < PMID: 11259604 > | Kirman I, Jenkins D, Fowler R, Whelan RL: Naturally occurring antibodies to epithelial cell adhesion molecule (EpCAM). Dig Dis Sci. 2003 Dec; 48(12):2306‑9. < PMID: 14714617 > | Winter MJ, Nagtegaal ID, van Krieken JH, Litvinov SV: The epithelial cell adhesion molecule (Ep‑CAM) as a morphoregulatory molecule is a tool in surgical pathology. Am J Pathol. 2003 Dec; 163(6):2139‑48. < PMID: 14633587 >

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