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CyFlow™ CD305 PerCP-Cy5.5

CyFlow™ CD305 PerCP-Cy5.5
Alternative Name: LAIR-1, LAIR1
Antibody: Yes
Antigen: CD305
Application: Flow cytometry
Clonality: monoclonal
Clone: NKTA255
Emission Maximum: 695 nm
Excitation Maximum: 482 nm
Field of Interest: Immunophenotyping
Format/Fluorochrome: PerCP-Cy5.5
Isotype: IgG1
Laser: Blue , Green
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: CT614380

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Description Documentation TDS & SDS
Description
Quantity 100 tests Volume 0.4 mL Immunogen Activated NK cells and CD3- thymocytes... more
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CyFlow™ CD305 PerCP-Cy5.5

Quantity100 tests
Volume0.4 mL
ImmunogenActivated NK cells and CD3- thymocytes
Background InformationCD305 (LAIR1; leukocyte-associated Ig-like receptor 1) is an inhibitory receptor found on many types of peripheral blood cells. It serves to suppress cell cytotoxicity, activation, proliferation, and differentiation regarding autoantigens via its two intracellular ITIM sites. CD305 belongs to the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family of proteins. It reacts with collagen ligands.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Poggi A, Pella N, Morelli L, Spada F, Revello V, Sivori S, Augugliaro R, Moretta L, Moretta A: p40, a novel surface molecule involved in the regulation of the non‑major histocompatibility complex‑restricted cytolytic activity in humans. Eur J Immunol. 1995 Feb; 25(2):369‑76. < PMID: 7875198 > | Poggi A, Tomasello E, Revello V, Nanni L, Costa P, Moretta L: p40 molecule regulates NK cell activation mediated by NK receptors for HLA class I antigens and TCR‑mediated triggering of T lymphocytes. Int Immunol. 1997 Sep; 9(9):1271‑9. < PMID: 9310830 > | Poggi A, Tomasello E, Ferrero E, Zocchi MR, Moretta L: p40/LAIR‑1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte‑monocyte colony‑stimulating factor. Eur J Immunol. 1998 Jul; 28(7):2086‑91. < PMID: 9692876 > | Warren HS: The Eighth Human Leucocyte Differentiation Antigen (HLDA8) Workshop: natural killer cell section report. Cell Immunol. 2005 Jul-Aug; 236(1‑2):17‑20. < PMID: 16157321 > | Meyaard L: The inhibitory collagen receptor LAIR‑1 (CD305). J Leukoc Biol. 2008 Apr; 83(4):799‑803. < PMID: 18063695 > | Colombo BM, Canevali P, Magnani O, Rossi E, Puppo F, Zocchi MR, Poggi A: Defective expression and function of the leukocyte associated Ig‑like receptor 1 in B lymphocytes from systemic lupus erythematosus patients. PLoS One. 2012; 7(2):e31903. < PMID: 22355402 > | Son M, Santiago-Schwarz F, Al-Abed Y, Diamond B: C1q limits dendritic cell differentiation and activation by engaging LAIR‑1. Proc Natl Acad Sci USA. 2012 Nov 13; 109(46):E3160‑7. < PMID: 23093673 >

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