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CyFlow™ CD271 Biotin

CyFlow™ CD271 Biotin
Alternative Name: LNGFR, NGFr(p75) , NTR, p75(NTR), TNFRSF16
Antibody: Yes
Antigen: CD271
Application: Flow cytometry
Clonality: monoclonal
Clone: NGFR5
Field of Interest: Immunophenotyping, Neurobiology
Format/Fluorochrome: Biotin
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Cat, Ferret, Human, Non-Human Primates, Rabbit
Product number: CN174919

For Research Use Only

$160.00 USD*

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ CD271 Biotin
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenPurified CD271 protein isolated from human melanoma cell line A875
Background InformationCD271 (NGFR, p75NGFR, p75NTR) is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.
UsageThe reagent is designed for indirect immunofluorescence analysis by Flow Cytometry. Suggested working usage is 5·µg/ml. Indicated dilution is recommended starting point for use of this product, but working concentrations should be validated by the investigator.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Marano N, Dietzschold B, Earley JJ Jr, Schatteman G, Thompson S, Grob P, Ross AH, Bothwell M, Atkinson BF, Koprowski H: Purification and amino terminal sequencing of human melanoma nerve growth factor receptor. J Neurochem. 1987 Jan; 48(1):225‑32. < PMID: 3025363 > | Schatteman GC, Gibbs L, Lanahan AA, Claude P, Bothwell M: Expression of NGF receptor in the developing and adult primate central nervous system. J Neurosci. 1988 Mar; 8(3):860‑73. < PMID: 2831315 > | Thompson SJ, Schatteman GC, Gown AM, Bothwell M: A monoclonal antibody against nerve growth factor receptor: Immunohistochemical analysis of normal and neoplastic human tissue. Am J Clin Pathol. 1989 Oct; 92(4):415‑23. < PMID: 2552791 > | Alpers CE, Hudkins KL, Ferguson M, Johnson RJ, Schatteman GC, Bothwell M: Nerve growth factor receptor expression in fetal, mature, and diseased human kidneys. Lab Invest. 1993 Dec; 69(6):703‑13. < PMID: 7903404 >

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