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CyFlow™ CD264 Azide Free

CyFlow™ CD264 Azide Free
Alternative Name: DCR2, TNFRSF10d, TRAILR4 , TRUNDD
Antibody: Yes
Antigen: CD264
Application: Flow cytometry
Clonality: monoclonal
Clone: TRAIL-R4-01
Field of Interest: Apoptosis, Immunophenotyping
Format/Fluorochrome: Azide Free
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: CH296525

For Research Use Only

$120.00 USD*

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ CD264 Azide Free
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenTRAIL-R4 (aa 1-210) - hIgGhc fusion protein
Background InformationCD264 (TRAIL-R4, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumor cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).
Storage BufferThe reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Sanlioglu AD, Dirice E, Aydin C, Erin N, Koksoy S, Sanlioglu S: Surface TRAIL decoy receptor‑4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells. BMC Cancer. 2005 May 25; 5(1):54. < PMID: 18518976 > | Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo MJ, Chan FK: Preligand assembly domain‑mediated ligand‑independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL‑induced apoptosis. Proc Natl Acad Sci USA. 2005 Dec 13; 102(50):18099‑104. < PMID: 16319225 > | Mérino D, Lalaoui N, Morizot A, Schneider P, Solary E, Micheau O: Differential inhibition of TRAIL‑mediated DR5‑DISC formation by decoy receptors 1 and 2. Mol Cell Biol. 2006 Oct; 26(19):7046‑55. < PMID: 16980609 > | Deligezer U, Dalay N: Expression of the TRAIL Receptors in Blood Mononuclear Cells in Leukemia. Pathol Oncol Res. 2007; 13(4):290‑4. < PMID: 18158563 > | Falschlehner C, Emmerich CH, Gerlach B, Walczak H: TRAIL signalling. Int J Biochem Cell Biol. 2007; 39(7‑8):1462‑75. < PMID: 17403612 >

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