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CyFlow™ CD206 PE

CyFlow™ CD206 PE
Alternative Name: CLEC13D , Macrophage mannose receptor
Antibody: Yes
Antigen: CD206
Application: Flow cytometry
Clonality: monoclonal
Clone: 15-2
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Field of Interest: Immunophenotyping
Format/Fluorochrome: PE
Isotype: IgG1
Laser: Blue , Green, Yellow
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: CK637501

For Research Use Only

$255.00 USD*

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Description
Quantity 100 tests Volume 1.0 mL Immunogen Purified human mannose receptor... more
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CyFlow™ CD206 PE
Quantity100 tests
Volume1.0 mL
ImmunogenPurified human mannose receptor
Background InformationCD206 (MMR; macrophage mannose receptor or MRC1; mannose receptor C1) is a type I transmembrane glycoprotein serving as pattern recognition receptor for carbogydrate groups on the surface of bacteria, fungi and other pathogens. Expressed mainly on tissue macrophages and dendritic cells, CD206 mediates endocytosis of these pathogens and presentation of their antigens to the adaptive immune system. CD206 can also be detected in a soluble form in human plasma and is elevated in patients with acute sepsis.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Mason D, Simmons D, Buckley C, Schwartz-Albiez R, Hadam M, Saalmuller A, Clark E, Malavasi F, Morrissey JA (Eds): Leucocyte Typing VII. Oxford University Press. 2002; 1‑945. < NLM ID: 101177131 > | Chang YC, Hsu TL, Lin HH, Chio CC, Chiu AW, Chen NJ, Lin CH, Hsieh SL: Modulation of macrophage differentiation and activation by decoy receptor 3. J Leukoc Biol. 2004 Mar; 75(3):486‑94. < PMID: 14657214 > | Torrelles JB, Azad AK, Schlesinger LS: Fine discrimination in the recognition of individual species of phosphatidyl‑myo‑inositol mannosides from Mycobacterium tuberculosis by C‑type lectin pattern recognition receptors. J Immunol. 2006 Aug 1; 177(3):1805‑16. < PMID: 16849491 > | Sturge J, Todd SK, Kogianni G, McCarthy A, Isacke CM: Mannose receptor regulation of macrophage cell migration. J Leukoc Biol. 2007 Sep; 82(3):585‑93. < PMID: 17596337 > | Shan M, Klasse PJ, Banerjee K, Dey AK, Iyer SP, Dionisio R, Charles D, Campbell-Gardener L, Olson WC, Sanders RW, Moore JP: HIV‑1 gp120 mannoses induce immunosuppressive responses from dendritic cells. PLoS Pathog. 2007 Nov; 3(11):e169. < PMID: 17983270 > | Sindrilaru A, Peters T, Wieschalka S, Baican C, Baican A, Peter H, Hainzl A, Schatz S, Qi Y, Schlecht A, Weiss JM, Wlaschek M, Sunderkötter C, Scharffetter-Kochanek K: An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest. 2011 Mar; 121(3):985‑97. < PMID: 21317534 >

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