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CyFlow™ CD205 PE

CyFlow™ CD205 PE
Alternative Name: CLEC13B, DEC-205 , GP200-MR6, lymphocyte Ag 75
Antibody: Yes
Antigen: CD205
Application: Flow cytometry
Clonality: monoclonal
Clone: HD30
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Field of Interest: Immunophenotyping
Format/Fluorochrome: PE
Isotype: IgG1
Laser: Blue , Green, Yellow
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: AB042675

For Research Use Only

$255.00 USD*

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Description
Quantity 100 tests Volume 1.0 mL Immunogen Recombinant Fc-tagged human CD205... more
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CyFlow™ CD205 PE
Quantity100 tests
Volume1.0 mL
ImmunogenRecombinant Fc-tagged human CD205
Background InformationCD205 (DEC-205) is an endocytic receptor of macrophage mannose receptor family. This 205 kDa C-type lectin transmembrane protein mediates adsorptive uptake and its intracellular domain contains coated pit localization sequence and distal acidic motif, which is required for recycling beyond early endosomes through deeper MHC II+ late endosomes and lysosomes. This unique pathway of receptor-mediated uptake proves to be necessary for presentation of antigenic peptides at low doses of ligand. CD205 is responsible for uptake and processing of captured antigens for dendritic cells.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Guo M, Gong S, Maric S, Misulovin Z, Pack M, Mahnke K, Nussenzweig MC, Steinman RM: A monoclonal antibody to the DEC‑205 endocytosis receptor on human dendritic cells. Hum Immunol. 2000 Aug; 61(8):729‑38. < PMID: 10980384 > | Mahnke K, Guo M, Lee S, Sepulveda H, Swain SL, Nussenzweig M, Steinman RM: The dendritic cell receptor for endocytosis, DEC‑205, can recycle and enhance antigen presentation via major histocompatibility complex class II‑positive lysosomal compartments. J Cell Biol. 2000 Oct 30; 151(3):673‑84. < PMID: 11062267 > | Gurer C, Strowig T, Brilot F, Pack M, Trumpfheller C, Arrey F, Park CG, Steinman RM, Münz C: Targeting the nuclear antigen 1 of Epstein‑Barr virus to the human endocytic receptor DEC‑205 stimulates protective T‑cell responses. Blood. 2008 Aug 15; 112(4):1231‑9. < PMID: 18519810 > | Park CG, Rodriguez A, Ueta H, Lee H, Pack M, Matsuno K, Steinman RM: Generation of anti‑human DEC205/CD205 monoclonal antibodies that recognize epitopes conserved in different mammals. J immunol Methods. 2012 Mar 30; 377(1‑2):15‑22. < PMID: 22273672 >

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