Article successfully added.

CyFlow™ CD203c Purified

CyFlow™ CD203c Purified
Alternative Name: B10, E-NPP3 , NPP3, PD-1b, PDNP3
Antibody: Yes
Antigen: CD203c
Application: Flow cytometry, Immunocytochemistry
Clonality: monoclonal
Clone: NP4D6
Field of Interest: Immunophenotyping
Format/Fluorochrome: Purified
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: CJ594252

For Research Use Only

$120.00 USD*

Price excludes any applicable taxes plus shipping costs

Description Documentation TDS & SDS
Description
HLDA Workshop HLDA VIII Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg... more
Close menu
CyFlow™ CD203c Purified
HLDA WorkshopHLDA VIII
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenHEK-293 cells transfected with human CD203c
Background InformationCD203c (ENPP-3) is integral membrane ectoenzyme (ectonucleotide pyrophosphatase/phosphodiesterase 3), that hydrolyses nucleotide triphosphates and thus modulates purinergic signaling. CD203c is expressed mainly on activated basophils and mast cells. CD203c is upregulated in response to IgE-receptor cross-linking and is overexpressed on neoplastic mast cells in patients with systemic mastocytosis. Measurement of its induced enhancement on the plasma membrane is useful for diagnostics of allergies.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Bühring HJ, Simmons PJ, Pudney M, Müller R, Jarrossay D, van Agthoven A, Willheim M, Brugger W, Valent P, Kanz L: The monoclonal antibody 97A6 defines a novel surface antigen expressed on human basophils and their multipotent and unipotent progenitors. Blood. 1999 Oct 1; 94(7):2343‑56. < PMID: 10498606 > | Bühring HJ, Seiffert M, Giesert C, Marxer A, Kanz L, Valent P, Sano K: The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 31. Blood. 2001 May 15; 97(10):3303‑5. < PMID: 11342463 > | Platz IJ, Binder M, Marxer A, Lischka G, Valent P, Bühring HJ: Hymenoptera‑venom‑induced upregulation of the basophil activation marker ecto‑nucleotide pyrophosphatase/phosphodiesterase 3 in sensitized individuals. Int Arch Allergy Immunol. 2001 Dec; 126(4):335‑42. < PMID: 11815741 > | Hauswirth AW, Escribano L, Prados A, Nuñez R, Mirkina I, Kneidinger M, Florian S, Sonneck K, Vales A, Schernthaner GH, Sanchez-Muñoz L, Sperr WR, Bühring HJ, Orfao A, Valent P: CD203c is overexpressed on neoplastic mast cells in systemic mastocytosis and is upregulated upon IgE receptor cross‑linking. Int J Immunopathol Pharmacol. 2008 Oct-Dec; 21(4):797‑806. < PMID: 19144265 > | Wanich N, Nowak-Wegrzyn A, Sampson HA, Shreffler WG: Allergen‑specific basophil suppression associated with clinical tolerance i patients with milk allergy. J Allergy Clin Immunol. 2009 Apr; 123(4):789‑94e20. < PMID: 19348919 > | Tokuda R, Nagao M, Hiraguchi Y, Hosoki K, Matsuda T, Kouno K, Morita E, Fujisawa T: Antigen‑induced expression of CD203c on basophils predicts IgE‑mediated wheat allergy. Allergol Int. 2009 Jun; 58(2):193‑9. < PMID: 19240377 > | Chirumbolo S, Brizzi M, Ortolani R, Vella A, Bellavite P: Inhibition of CD203c membrane up‑regulation in human basophils by high dilution of histamine: a controlled replication study. Inflamm Res. 2009 Nov; 58(11):755‑64. < PMID: 19418203 >

TDS & SDS
Close menu

Technical Data Sheet

Safety Data Sheet