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CyFlow™ CD195 PE

CyFlow™ CD195 PE
Alternative Name: CC-CKR5, CCR5 , CKR5, CMKBR5
Antibody: Yes
Antigen: CD195
Application: Flow cytometry
Clonality: monoclonal
Clone: T21/8
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Field of Interest: Immunophenotyping, Signaling
Format/Fluorochrome: PE
Isotype: IgG1
Laser: Blue , Green, Yellow
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: AH378490

For Research Use Only

$255.00 USD*

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Description
Quantity 100 tests Volume 1.0 mL Immunogen CCR5 peptide (Met1-Lys22) KLH conjugate... more
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CyFlow™ CD195 PE
Quantity100 tests
Volume1.0 mL
ImmunogenCCR5 peptide (Met1-Lys22) KLH conjugate
Background InformationCD195 (CCR5, CKR-5) is a receptor for inflammatory CC-chemokines (characterized by a pair of adjacent cysteine residues), such as MIP-1 α, MIP-1 β, or RANTES. It is a G protein-associated seven-pass transmembrane protein expressed on resting T cells with memory/effector phenotype, monocytes, macrophages and immature dendritic cells. This chemokine receptor regulates the activation and directed migration of leukocytes. Importantly, along with CD4, CD195 functions as a major receptor for HIV. Their ligand is the viral glycoprotein gp120.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Pollok-Kopp B, Schwarze K, Baradari VK, Oppermann M: Analysis of ligand‑stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite‑specific antibodies. J Biol Chem. 2003 Jan 24; 278(4):2190‑8. < PMID: 12403770 > | Hüttenrauch F, Pollok-Kopp B, Oppermann M: G protein‑coupled receptor kinases promote phosphorylation and beta‑arrestin‑mediated internalization of CCR5 homo‑ and hetero‑oligomers. J Biol Chem. 2005 Nov 11; 280(45):37503‑15. < PMID: 16144840 > | Monde K, Maeda Y, Tanaka Y, Harada S, Yusa K: Gp120 V3‑dependent impairment of R5 HIV‑1 infectivity due to virion‑incorporated CCR5. J Biol Chem. 2007 Dec 21; 282(51):36923‑32. < PMID: 17971448 > | Mascalchi P, Lamort AS, Salomé L, Dumas F: Single Particle Tracking reveals two distinct environments for CD4 receptors at the surface of living T lymphocytes. Biochem Biophys Res Commun. 2012 Jan 6; 417(1):409‑13. < PMID: 22166195 >

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