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CyFlow™ CD161 Purified

CyFlow™ CD161 Purified
Alternative Name: NKR, NKR-P1A , NKRP1A
Antibody: Yes
Antigen: CD161
Application: Flow cytometry, Immunohistochemistry (frozen sections), Immunoprecipitation, Radioimmunoassay, Western blot
Clonality: monoclonal
Clone: 10/78
Field of Interest: Immunophenotyping, MHC
Format/Fluorochrome: Purified
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Rat
Product number: BG633525

For Research Use Only

$120.00 USD*

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ CD161 Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenSplenic cells purified from the LEW rat
Background InformationCD161 (Nkrp1; natural killer receptor protein 1 or Klrb1; killer cell lectin-like receptor subfamily b member 1) is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Sedgwick JD, Ford AL, Foulcher E, Airriess R: Central nervous system microglial cell activation and proliferation follows direct interaction with tissue‑infiltrating T cell blasts. J Immunol. 1998 Jun 1; 160(11):5320‑30. < PMID: 9605131 > | Tliba O, Chauvin A, Le Vern Y, Boulard C, Sbille P: Evaluation of the hepatic NK cell response during the early phase of Fasciola hepatica infection in rats. Vet Res. 2002 May-Jun; 33(3):327‑32. < PMID: 12056483 > | May E, Dorris ML, Satumtira N, Iqbal I, Rehman MI, Lightfoot E, Taurog JD: CD8 alpha beta T cells are not essential to the pathogenesis of arthritis or colitis in HLA‑B27 transgenic rats. J Immunol. 2003 Jan 15; 170(2):1099‑105. < PMID: 12517979 > | Stephens LA, Barclay AN, Mason D: Phenotypic characterization of regulatory CD4+CD25+ T cells in rats. Int Immunol. 2004 Feb; 16(2):365‑75. < PMID: 14734622 > | Chang CJ, Tai KF, Roffler S, Hwang LH: The immunization site of cytokine‑secreting tumor cell vaccines influences the trafficking of tumor‑specific T lymphocytes and antitumor efficacy against regional tumors. J Immunol. 2004 Nov 15; 173(10):6025‑32. < PMID: 15528337 > | Teshima R, Nakamura R, Nakamura R, Hachisuka A, Sawada JI, Shibutani M: Effects of exposure to decabromodiphenyl ether on the development of the immune system in rats. J Health Sci. 2008; 54(4):382‑389. < No PMID > | Kraszula L, Eusebio M, Kupczyk M, Kuna P, Pietruczuk M: The use of multi‑color flow cytometry for identification of functional markers of nTregs in patients with severe asthma. Pneumonol Alergol Pol. 2012; 80(5):389‑401. < PMID: 22926900 >

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