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CyFlow™ CD160 PE

CyFlow™ CD160 PE
Alternative Name: BY55 , NK1, NK28
Antibody: Yes
Antigen: CD160
Application: Flow cytometry
Clonality: monoclonal
Clone: BY55
Emission Maximum: 576 nm
Excitation Maximum: 496 nm, 565 nm
Field of Interest: Immunophenotyping
Format/Fluorochrome: PE
Isotype: IgM
Laser: Blue , Green, Yellow
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: CL791330

For Research Use Only

$255.00 USD*

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Description Documentation TDS & SDS
Description
Quantity 100 tests Volume 1.0 mL Immunogen Human NK cell line YT2C2 Background... more
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CyFlow™ CD160 PE
Quantity100 tests
Volume1.0 mL
ImmunogenHuman NK cell line YT2C2
Background InformationCD160 is a cell surface glycoprotein of immunoglobulin superfamily, which functions as a costimulatory receptor expressed mainly on cytotoxic cell populations and recognizing both classical and non-classical MHC class I molecules. It can form disulfide-linked multimers. Down-modulation of CD160 occurs as a consequence of its proteolytic cleavage and the released soluble form was found to impair the MHC-class I specific cytotoxicity of CD8+ T lymphocytes and NK cells. In contrast to GPI-anchored isoform with broader expression among CD160 positive cells, expression of the transmembrane isoform is restricted to NK cells and is activation-dependent.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing Tris buffered saline (TBS) solution, pH ≈8.0, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Maïza H, Leca G, Mansur IG, Schiavon V, Boumsell L, Bensussan A: A novel 80‑kD cell surface structure identifies human circulating lymphocytes with natural killer activity. J Exp Med. 1993 Sep 1; 178(3):1121‑6. < PMID: 7688788 > | Bensussan A, Gluckman E, el Marsafy S, Schiavon V, Mansur IG, Dausset J, Boumsell L, Carosella E: BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic activity. Proc Natl Acad Sci USA. 1994 Sep 13; 91(19):9136‑40. < PMID: 8090781 > | Anumanthan A, Bensussan A, Boumsell L, Christ AD, Blumberg RS, Voss SD, Patel AT, Robertson MJ, Nadler LM, Freeman GJ: Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J Immunol. 1998 Sep 15; 161(6):2780‑90. < PMID: 9743336 > | Merino J, Ramírez N, Moreno C, Toledo E, Fernández M, Sánchez-Ibarrola A: BY55/CD160 cannot be considered a cytotoxic marker in cytomegalovirus‑specific human CD8(+) T cells. Clin Exp Immunol. 2007 Jul; 149(1):87‑96. < PMID: 17425655 > | Giustiniani J, Bensussan A, Marie-Cardine A: Identification and characterization of a transmembrane isoform of CD160 (CD160‑TM), a unique activating receptor selectively expressed upon human NK cell activation. J Immunol. 2009 Jan 1; 182(1):63‑71. < PMID: 19109136 >

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