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CyFlow™ CD158d Purified

CyFlow™ CD158d Purified
Alternative Name: 15.212, 103AS, KIR2DL4 , KIR103, KIR103AS
Antibody: Yes
Antigen: CD158d
Application: Flow cytometry, Functional assays, Immunocytochemistry, Immunoprecipitation, Western blot
Clonality: monoclonal
Clone: mAb#33
Field of Interest: Immunophenotyping
Format/Fluorochrome: Purified
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: AT204672

For Research Use Only

$120.00 USD*

Price excludes any applicable taxes plus shipping costs

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Description
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
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CyFlow™ CD158d Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenNK3.3 cells and KIR2DL4-Ig fusion protein
Background InformationCD158d (KIR2DL4) is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-γ secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Rajagopalan S, Fu J, Long EO: Cutting edge: induction of IFN‑gamma production but not cytotoxicity by the killer cell Ig‑like receptor KIR2DL4 (CD158d) in resting NK cells. J Immunol. 2001 Aug 15; 167(4):1877‑81. < PMID: 11489965 > | Goodridge JP, Witt CS, Christiansen FT, Warren HS: KIR2DL4 (CD158d) genotype influences expression and function in NK cells. J Immunol. 2003 Aug 15; 171(4):1768‑74. < PMID: 12902476 > | Yan WH, Fan LA: Residues Met76 and Gln79 in HLA‑G alpha1 domain involve in KIR2DL4 recognition. Cell Res. 2005 Mar; 15(3):176‑82. < PMID: 15780179 > | LeMaoult J, Zafaranloo K, Le Danff C, Carosella ED: HLA‑G up‑regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells. FASEB J. 2005 Apr; 19(6):662‑4. < PMID: 15670976 > | Rajagopalan S, Bryceson YT, Kuppusamy SP, Geraghty DE, van der Meer A, Joosten I, Long EO: Activation of NK cells by an endocytosed receptor for soluble HLA‑G. PLoS Biol. 2006 Jan; 4(1):e9. < PMID: 16366734 >

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