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CyFlow™ CD157 APC

CyFlow™ CD157 APC
Alternative Name: BP-3/IF7, BST1, cADPr hydrolase 2, Mo5
Antibody: Yes
Antigen: CD157
Application: Flow cytometry
Clonality: monoclonal
Clone: SY11B5
Emission Maximum: 660 nm
Excitation Maximum: 650 nm
Field of Interest: Immunophenotyping
Format/Fluorochrome: APC
Isotype: IgG1
Laser: Red
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human, Non-Human Primates
Product number: CB736754

For Research Use Only

$255.00 USD*

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Description Documentation TDS & SDS
Description
Quantity 100 tests Volume 1.0 mL Immunogen Human CD157 Background Information... more
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CyFlow™ CD157 APC
Quantity100 tests
Volume1.0 mL
ImmunogenHuman CD157
Background InformationCD157 (cADPr hydrolase 2, BST1, BP-3/IF7, Mo5) is a GPI-anchored ectoenzyme possessing ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activity. It uses NAD and cADP-ribose as substrates. CD157 is expressed on granulocytes, monocytes, macrophages, follicular dendritic cells, bone marrow stromal cells and human umbilical cord vein endothelial cells. In case of rheumatoid arthritis the expression is often higher and it is also differentially expressed in the myeloid leukemias. It may also have a signaling role.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 10·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Sutherland R, Acton E, Keeney M, Borowitz M, Richards S, Fletcher M, Whitby L, Barnett D, Illingworth A: Recommended antibody clones and conjugates suitable for high-sensitivity flow cytometric detection of PNH Red (RBC) and White (WBC) Blood Cells. Cytometry Part B: Clinical Cytometry. 2013 Nov 1; 84(6):422-3. < No PMID > | Sutherland DR, Acton E, Keeney M, Davis BH, Illingworth A: Use of CD in FLAER‐based assays for high‐sensitivity PNH granulocyte and PNH monocyte detection. Cytometry Part B: Clinical Cytometry. 2014 Jan 1; 86(1):44-55. < PMID: 23922226 > | Marinov I, Kohoutová M, Tkáčová V, Pešek A, Čermák J, Cetkovský P: Clinical relevance of CD for rapid and cost‐effective simultaneous evaluation of PNH granulocytes and monocytes by flow cytometry. Int J Lab Hematol. 2015 Apr; 37(2):231-7. < PMID: 24963875 > | Arriga R, Caratelli S, Coppola A, Spagnoli GC, Venditti A, Amadori S, Lanzilli G, Lauro D, Palomba P, Sconocchia T, Del Principe MI: Enhancement of anti-leukemia activity of NK cells in vitro and in vivo by inhibition of leukemia cell-induced NK cell damage. Oncotarget. 2016 Jan 12; 7(2):2070. < PMID: 26655503 > | Marinov I, Illingworth AJ, Benko M, Sutherland DR: Performance characteristics of a non‐FLAER‐based PNH assay for simultaneous evaluation of PNH neutrophils and PNH monocytes by flow cytometry, following published PNH guidelines. Cytometry B Clin Cytom. 2016 Jun 13; < PMID: 27294344 >

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