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CyFlow™ CD61 Purified

CyFlow™ CD61 Purified
Alternative Name: GPIIIa
Antibody: Yes
Antigen: CD61
Application: Flow cytometry, Immunohistochemistry (frozen sections), Western blot
Clonality: monoclonal
Clone: VIPL2
Field of Interest: Immunophenotyping
Format/Fluorochrome: Purified
Isotype: IgG1
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human, Non-Human Primates
Product number: BH224849

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Description
HLDA Workshop HLDA V—WS Code 5T-124 Concentration Unit mg/mL Concentration 1... more
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CyFlow™ CD61 Purified
HLDA WorkshopHLDA V—WS Code 5T-124
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenNot available
Background InformationCD61 (β3 integrin) is a transmembrane glycoprotein, which associates with CD41 or CD51 molecules to form heterodimeric adhesion receptores. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. It binds to fibronectin, fibrinogen and von Willebrand factor, and is involved in platelet aggregation. CD51/CD61 complex has similar binding properties and is involved in modulating migration and survival of angiogenic endothelial cells.
Storage BufferThe reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Dzionek A, Fuchs A, Schmidt P, Cremer S, Zysk M, Miltenyi S, Buck DW, Schmitz J: BDCA‑2, BDCA‑3, and BDCA‑4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol. 2000 Dec 1; 165(11):6037‑46. < PMID: 11086035 > | Ciarlet M, Crawford SE, Cheng E, Blutt SE, Rice DA, Bergelson JM, Estes MK: VLA‑2 (alpha2beta{01} integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment. J Virol. 2002 Feb; 76(3):1109‑23. < PMID: 11773387 > | Roberts MS, Woods AJ, Dale TC, Van Der Sluijs P, Norman JC: Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins. Mol Cell Biol. 2004 Feb; 24(4):1505‑15. < PMID: 14749368 > | Mondal D, Williams CA, Ali M, Eilers M, Agrawal KC: The HIV‑1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells. Exp Biol Med (Maywood). 2005 Oct; 230(9):631‑44. < PMID: 16179731 > | Williams CA, Mondal D, Agrawal KC: The HIV‑1 Tat protein enhances megakaryocytic commitment of K562 cells by facilitating CREB transcription factor coactivation by CBP. Exp Biol Med (Maywood). 2005 Dec; 230(11):872‑84. < PMID: 16339753 > | Barrett L, Dai C, Gamberg J, Gallant M, Grant M: Circulating CD14‑CD36+ peripheral blood mononuclear cells constitutively produce interleukin‑10. J Leukoc Biol. 2007 Jul; 82(1):152‑60. < PMID: 17412916 >

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