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CyFlow™ CD7 PE-Cy7

CyFlow™ CD7 PE-Cy7
Alternative Name: gp40
Antibody: Yes
Antigen: CD7
Application: Flow cytometry
Clonality: monoclonal
Clone: MEM-186
Emission Maximum: 785 nm
Excitation Maximum: 496 nm, 565 nm
Field of Interest: Immunophenotyping
Format/Fluorochrome: PE-Cy7
Isotype: IgG1
Laser: Blue , Green, Yellow
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: AX688205

For Research Use Only

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Description Documentation TDS & SDS
Description
HLDA Workshop HLDA VI—WS Code T 6T-015 Quantity 100 tests Volume 0.4 mL Immunogen... more
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CyFlow™ CD7 PE-Cy7
HLDA WorkshopHLDA VI—WS Code T 6T-015
Quantity100 tests
Volume0.4 mL
ImmunogenHuman Acute Myelogenous Leukemia (AML) KG-1 cells
Background InformationCD7 (gp40) is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 co-stimulation can induce cytokine secretion and modulate cellular adhesion. A ligand of CD7, epithelial cell secreted protein K12, is produced in thymus to regulate thymocyte signaling and cytokine release. In lung microvascular endothelial cells CD7 serves as an IgM Fc receptor.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Kishimoto T, Goyert S, Kikutani H, Mason D, Miyasaka M, Moretta L, Ohno T, Okumura K, Shaw S, Springer TA, Sugamura K, Sugawara H, von dem Borne AEGK, Zola H (Eds): Leucocyte Typing VI. Garland Publishing Inc, New York. 1997; 1‑1342. < NLM ID: 9712219 > | Alaibac M, Pigozzi B, Belloni-Fortina A, Michelotto A, Saponeri A, Peserico A: CD7 expression in reactive and malignant human skin T‑lymphocytes. Anticancer Res. 2003 May-Jun; 23(3B):2707‑10. < PMID: 12894562 > | Lam GK, Liao HX, Xue Y, Alam SM, Scearce RM, Kaufman RE, Sempowski GD, Haynes BF: Expression of the CD7 ligand K‑12 in human thymic epithelial cells: regulationby IFN‑gamma. J Clin Immunol. 2005 Jan; 25(1):41‑9. < PMID: 15742156 > | Nishimura M, Takanashi M, Okazaki H, Satake M, Nakajima K: Role of CD7 expressed in lung microvascular endothelial cells as Fc receptor for immunoglobulin M. Endothelium. 2006 Jul-Aug; 13(4):287‑92. < PMID: 16990185 > | Chang H, Yeung J, Brandwein J, Yi QL: CD7 expression predicts poor disease free survival and post‑remission survival in patients with acute myeloid leukemia and normal karyotype. Leuk Res. 2007 Feb; 31(2):157‑62. < PMID: 16837044 >

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