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CyFlow™ CD2 APC-Cy7

CyFlow™ CD2 APC-Cy7
Alternative Name: LFA-2
Antibody: Yes
Antigen: CD2
Application: Flow cytometry
Clonality: monoclonal
Clone: TS1/8
Emission Maximum: 780 nm
Excitation Maximum: 650 nm, 750 nm
Field of Interest: Immunophenotyping
Format/Fluorochrome: APC-Cy7
Isotype: IgG1
Laser: Red
Regulatory Status: RUO
Source Species: Mouse
Target Species: Human
Product number: CR042022

For Research Use Only

$295.00 USD*

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Description Documentation TDS & SDS
Description
HLDA Workshop HLDA V—WS Code S025 Quantity 100 tests Volume 0.4 mL Immunogen... more
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CyFlow™ CD2 APC-Cy7
HLDA WorkshopHLDA V—WS Code S025
Quantity100 tests
Volume0.4 mL
ImmunogenCytotoxic T lymphocytes
Background InformationCD2 (LFA-2) belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.
UsageThe reagent is designed for Flow Cytometry analysis of human blood cells. Recommended usage is 4·µl reagent·/ 100·µl of whole blood or 10^6 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
Storage BufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Specific References

| Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA: Three distinct antigens associated with human T‑lymphocyte‑mediated cytolysis: LFA‑1, LFA‑2, and LFA‑3. Proc Natl Acad Sci USA. 1982 Dec; 79(23):7489‑93. < PMID: 6984191 > | Vollger LW, Tuck DT, Springer TA, Haynes BF, Singer KH: Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD‑2 and LFA‑3 antigens. J Immunol. 1987 Jan 15; 138(2):358‑63. < PMID: 3098838 > | Doussis IA, Gatter KC, Mason DY: CD68 reactivity of non‑macrophage derived tumours in cytological specimens. J Clin Pathol. 1993 Apr; 46(4):334‑6. < PMID: 7684403 > | Zhang B, Dai M, Li QJ, Zhuang Y: Tracking proliferative history in lymphocyte development with cre‑mediated sister chromatid recombination. PLoS Genet. 2013 Oct; 9(10):e1003887. < PMID: 24204301 >

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