CyFlow™ CD17 Purified

CyFlow™ CD17 Purified
Target Species: Human
Antigen: CD17
Field of Interest: Immunophenotyping
Clone: MEM-68
Regulatory Status: RUO
Alternative Name: Lactosylceramide
Application: Flow cytometry
Format/Fluorochrome: Purified
Species of Origin: Mouse
Clonality: monoclonal
Isotype: IgM
Product number: CX623074

For Research Use Only

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Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Immunogen Pre-B cell... more
CyFlow™ CD17 Purified
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
ImmunogenPre-B cell line NALM-6
SpecifityThe mouse monoclonal antibody MEM-68 recognizes CD17 antigen, a membrane lipid moiety lactosylceramide expressed on granulocytes, monocytes and platelets.
Background InformationCD17 (lactosylceramide) is an ubiquitous glycosphingolipid with uncharged disaccharide headgroup, highly enriched in lipid raft-derived structures. Besides playing a pivotal role in the biosynthesis of complex glycosphingilipids, lactosylceramide is involved in cell-cell and cell-matrix interactions and in signaling events linked to cell differentiation, development, apoptosis and oncogenesis. Lactosylceramide regulates integrin functions and production of nitric oxide. Its expression defines successive stages in the maturation of myeloid cells.
Storage BufferThe reagent is provided in Tris buffered saline (TBS) solution, pH ≈8.0, containing 0.1% (w/v) sodium azide.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.

Specific References

| Bhunia AK, Arai T, Bulkley G, Chatterjee S: Lactosylceramide mediates tumor necrosis factor‑alpha‑induced intercellular adhesion molecule‑1 (ICAM‑1 expression and the adhesion of neutrophil in human umbilical vein endothelial cells. J·Biol·Chem. 1998·Dec·18; 273(51):34349‑57. <·PMID:·9852101·> | Spychalska J, Smoleńska-Sym G, Zdebska E, Woźniak J, Kościelak J: Quantitative analysis of LacCer/CDw17 in human myelogenous leukaemic cells. Cell·Mol·Biol·Lett. 2003; 8(4):911‑7. <·PMID:·14668914·> | Pannu R, Singh AK, Singh I: A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha‑mediated proliferation of rat primary astrocytes: Implications for astrogliosis following neurotrauma. J·Biol·Chem. 2005·Apr·8; 280(14):13742‑51. <·PMID:·15668227·> | Sharma DK, Brown JC, Cheng Z, Holicky EL, Marks DL, Pagano RE: The glycosphingolipid, lactosylceramide, regulates beta1‑integrin clustering and endocytosis. Cancer·Res. 2005·Sep·15; 65(18):8233‑41. <·PMID:·16166299·> | Zhai X, Li XM, Momsen MM, Brockman HL, Brown RE: Lactosylceramide: lateral interactions with cholesterol. Biophys·J. 2006·Oct·1; 91(7):2490‑500. <·PMID:·16829567·>

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